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For Skin And Hair Enhancement​.

Mannofit product prevents acne, painful spots, and blackheads as it has been found that vitamin A deficiency increases the risk of having acne due to the overproduction of protein keratin in the hair follicles.

This product has a potential aid in decreasing the risk of developing skin cancer. This depends on its contents as vitamin A and lycopene, which have been found through clinical research that they have strong antioxidants.

Mannofit helps to maintain healthy hair. It prevents hair loss as it secrets sebum which is a substance that prevents hair breakage. It also fights the free radicals that are not good for your hair.

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Vitamin A

Vitamin A and its derivatives like retinoids and carotenoids have a significant role in regulating proliferation, differentiation, and apoptosis of different cell types, including skin cells. (12).

Retinoids have effects on the skin through different mechanisms:

1) regulating the genes that are responsible for the expression of the epidermal structural and functional aspects via direct binding to RARs and/or RXRs (13).

2) adjusting skin-related genes by interfering with other transcriptional factors after receptor binding (14).

Retinoids could enhance the repair of ultraviolet irradiation-damaged skin through these mechanisms.

1) They can increase the proliferation of epidermal keratinocytes and dermal fibroblasts (15).         2) They inhibit the expression of matrix metalloproteinases (MMPs), matrix-degrading enzymes, and this ,in turn, leads to increased overall protein and extracellular matrix content (16).

Also, it had been observed that retinoids have important potential in the prevention and treatment of other skin diseases, like skin cancer and acne. (17,18)

Blackberry

There is no other component that can match this super item when it comes to a nutrient power that enhances healthy hair growth. It is rich in vitamin C, Berries feed hair follicles sufficiently ,and enhances blood circulation on the scalp. Berries contain vitamin B, which supplies enough oxygen to reach the cells and thus in turn leads to reduce hair loss, prevent the graying process, enhance hair growth and add softness and shine obviously to the hair. (19) 

Lycopene

Lycopene is one of the antioxidants that play a role in preventing any damage to the collagen in the skin. It helps prevent wrinkles, skin discoloration, texture changes, and fine lines. This is according to what Dr. Tsippora Shainhouse said. 

Increasing lycopene intake can boost the health of the collagen in the skin and stop some of the fine lines before they begin.

Lycopene can give its benefits to any skin type but works especially perfect for sensitive and aging skin.

It  also calms the body’s inflammatory process and this ,in turn, leads to reducing redness and irritation. Lycopene has perfect anti-aging properties it is beneficial to all kinds of skin.

There is a study in the British Journal of Dermatology established that lycopene supplements helped protect the skin from ultraviolet rays. So this component is one of the antioxidants that have a potential effect against sun damage.

Lycopene is one of the antioxidants that play a role in preventing any damage to the collagen in the skin. It helps prevent wrinkles, skin discoloration, texture changes, and fine lines. This is according to what Dr. Tsippora Shainhouse said. 

Increasing lycopene intake can boost the health of the collagen in the skin and stop some of the fine lines before they begin.

Lycopene can give its benefits to any skin type but works especially perfect for sensitive and aging skin.

It  also calms the body’s inflammatory process and this ,in turn, leads to reducing redness and irritation. Lycopene has perfect anti-aging properties it is beneficial to all kinds of skin. 

There is a study in the British Journal of Dermatology established that lycopene supplements helped protect the skin from ultraviolet rays. So this component is one of the antioxidants that have a potential effect against sun damage.

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REFERENCES

12) Retinoid-responsive transcriptional changes in epidermal keratinocytes. Lee DD, Stojadinovic O, Krzyzanowska A, Vouthounis C, Blumenberg M, Tomic-Canic M J Cell Physiol. 2009 Aug; 220(2):427-439.                                                                            

13) Specific organization of the negative response elements for retinoic acid and thyroid hormone receptors in keratin gene family. Radoja N, Diaz DV, Minars TJ, Freedberg IM, Blumenberg M, Tomic-Canic M J Invest Dermatol. 1997 Oct; 109(4):566-72.                                   

14) From an enhanceosome to a repressosome: molecular antagonism between glucocorticoids and EGF leads to inhibition of wound healing. Lee B, Vouthounis C, Stojadinovic O, Brem H, Im M, Tomic-Canic MJ Mol Biol. 2005 Feb 4; 345(5):1083-97.                                   

15) All-trans retinoic acid (RA) stimulates events in organ-cultured human skin that underlie repair. Adult skin from sun-protected and sun-exposed sites responds in an identical manner to RA while neonatal foreskin responds differently. Varani J, Perone P, Griffiths CE, Inman DR, Fligiel SE, Voorhees JJJ Clin Invest. 1994 Nov; 94(5):1747-56.

16) Pathophysiology of premature skin aging induced by ultraviolet light. Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ N Engl J Med. 1997 Nov 13; 337(20):1419-28.          

17) The use of retinoids in the prevention and treatment of skin cancer. Niles RM Expert Opin Pharmacother. 2002 Mar; 3(3):299-303.                    

18) The treatment of acne with topical retinoids: one man’s opinions. Kligman AM J Am Acad Dermatol. 1997 Jun; 36(6 Pt 2):S92-5.                

19) Hyunkyoung Lee, Na-Hyun Kim, Hyeryeon Yang, Seong Kyeong Bae, Yunwi Heo, Indu Choudhary, Young Chul Kwon, Jae Kuk Byun, Hyeong Jun Yim, Byung Seung Noh, Jeong-Doo Heo, Euikyung Kim, Changkeun Kang Evid Based Complement Alternat Med. 2016; 2016: 1873746

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