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For Heart & Blood Health Enhancement​.

This product supports the health of the body muscles as it contains various contents such as vitamin E that decreases the soreness of muscles and decreases also the free radicals as well based on clinical studies.

It supports the body muscles not only in healthy athletes, but also in elderly people as it carries anti-aging properties due to its antioxidants.

It supports the link between testosterone of the body and the muscles. The studies proved that vitamin b6 (one of the contents of Mannofit product) consumption stimulates the production of testosterone and it is proved scientifically that high testosterone is linked with big mass muscles and healthy muscles as well.

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Vitamin E

The most active important form of vitamin E is gamma-tocopherol. The science says that cardiovascular complications basically occur as a result of the presence of the oxidation of low-density lipoproteins in the body and the consequent inflammation. (1).

This vitamin improves cardiovascular functions by increasing the activity of nitric oxide synthase, which manufactures vessel-relaxing nitric oxide by snaring the reactive nitrogen species (peroxynitriten) molecules and in_turn enhancing the endothelial function occurs. (2).

The evidence here is that it had been observed that consuming specific safe amounts of this vitamin leads to a reduction in several risk factors for arterial clottings, such as platelet aggregation and cholesterol. (3).

In another study, a stronger inhibitory effect on lipid peroxidation and inhibition of human platelet aggregation occur related to the mixed tocopherols than individual tocopherols alone, suggesting a great benefit as a synergistic platelet-inhibitory effect. (4)

Vitamin B6

Vitamin B6 has a great benefit in preventing blocked arteries and decreasing heart disease risk. The evidence here is research that observed that people who have low blood levels of vitamin B6 have almost dual the risk of having heart disease compared to those with higher B6 levels. (6).

This returns to the role of this vitamin in decreasing elevated homocysteine levels. Elevated levels of this component are linked to several disease processes, including heart disease. (6)

There is another randomized controlled trial that had been done among 158 healthy adults who had siblings with heart disease. They were divided into two groups, one that received 250 mg of vitamin B6 and 5 mg of folic acid daily for two years and the others received a placebo. The results showed that the group that took B6 and folic acid had lower homocysteine levels and fewer abnormal heart tests during exercise than the placebo group. This made them at lower risks of having heart disease. (7)

Nettle

It had been proved that this component has a role in decreasing high blood pressure. And this had been established through several studies and clinical researches. Nettle can stimulate nitric oxide production, which acts as a vasodilator. It is known scientifically that vasodilators relax the muscles of the blood vessels, making them widen. (19).
Nettle has compounds that may act as calcium channel blockers, that have the ability to relax the heart by decreasing the force of contractions (20).
Besides these results, It had been shown through animal studies that nettle has the ability to lower blood pressure levels while raising the heart’s antioxidant defenses. (21).

Lycopene

It had been observed via several studies that lycopene has great anti-inflammatory effects that serve the cardiovascular system. lycopene has the ability to inhibit TNF-alpha which induced NF-kappa B activation, expression of intracellular adhesion molecule-1 (ICAM-1), and interaction between monocytes and endothelial cells, that can observe the cardiovascular benefits of lycopene. These anti-inflammatory effects are great as it is known scientifically that Inflammation is linked with atherosclerosis, arterial stiffness, and major cardiovascular events. (11).
Lycopene has the ability to decrease the secretion of metalloproteinases by macrophages and inhibit the process of T lymphocyte activation (12).
Recently, lycopene was observed as an effective antiglycation agent, which can decrease the synthesis of advanced glycation end-products (AGE), downregulating the expression of their receptors (RAGE), as a result, vessel protection can happen. (13).

Coenzyme q10

COQ10 plays a significant role in the heart’s energetic needs. As an example, the process of cardiac contraction, which involves the release of Ca2+ from the sarcoplasmic reticulum and the following activation of the contractile proteins requires energy. (14). There is a theory that observed that myocardial failure may be caused by the reduced production of energy in mitochondria. (15). However, COQ10 is the main component in the transport of electrons necessary for ATP production.
There are also some new studies that established the anti-inflammatory properties of COQ10 possibly by means of nitric oxide’s regulation, and this mechanism can be effective in heart failure. (16).

It had been observed that Coenzyme 10 has a role in the regulation and decreasing high blood pressure by adjusting the angiotensin effect in sodium retention and decreasing the level of aldosterone. (17).
This the effect was shown in a study where COQ10 was presented as an adjuvant to usual antihypertensive therapy to maintain serum level of COQ10 equal to 2.0 µg/ml. (18). Finally, they got their results which showed an improvement in functional and clinical condition within 6 months.

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REFERENCES

1)Tocotrienols potentiate lovastatin-mediated growth suppression in vitro and in vivo.McAnally JA, Gupta J, Sodhani S, Bravo L, Mo H
Exp Biol Med (Maywood). 2007 Apr; 232(4):523-31.

2) Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians’ Health Study II randomized controlled trial. Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Glynn RJ, Gaziano JM JAMA. 2008 Nov 12; 300(18):2123-33.

3) Experimental basis for cancer prevention by vitamin E. Shklar G, Oh SK Cancer Invest. 2000; 18(3):214-22.

4) Effects of gamma-tocopherol supplementation on thrombotic risk factors. Singh I, Turner AH, Sinclair AJ, Li D, Hawley JA Asia Pac J Clin Nutr. 2007; 16(3):422-8.

5) Pizzino G, Irrera N, Cucinotta M, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017;2017:8416763.

6) Lin PT, Cheng CH, Liaw YP, Lee BJ, Lee TW, Huang YC. Low pyridoxal 5′-phosphate is associated with increased risk of coronary artery disease. Nutrition. 2006 Nov-Dec;22(11-12):1146-51.

7) Vermeulen EG, Stehouwer CD, Twisk JW, van den Berg M, de Jong SC, Mackaay AJ, van Campen CM, Visser FC, Jakobs CA, Bulterjis EJ, Rauwerda JA. Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial. Lancet. 2000 Feb 12;355(9203):517-22.

12) Cardiovascular benefits of lycopene: fantasy or reality? Thies F, Mills LM, Moir S, Masson LF Proc Nutr Soc. 2017 May; 76(2):122-129.

13) Lycopene powers the inhibition of glycation-induced diabetic nephropathy: a novel approach to halt the AGE-RAGE axis menace. Tabrez S, Al-Shali KZ, Ahmad S Biofactors. 2015 Sep-Oct; 41(5):372-81.

14) Kayo C.Y., Carsten M.E. In: Cellular Aspects of Smooth Muscle Function. Pres C.U., editor. Cambridge University Press; 2005.

15) Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Kumar A, Kaur H, Devi P, Mohan V Pharmacol Ther. 2009 Dec; 124(3):259-68.

16) Evaluation of anti-angiogenic, anti-inflammatory and antinociceptive activity of coenzyme Q(10) in experimental animals. Jung HJ, Park EH, Lim CJ J Pharm Pharmacol. 2009 Oct; 61(10):1391-5.

17) Fabre L.F., Jr, Banks R.C., McIsaac W.M., Farrell G. Effects of ubiquinone and related substances on secretion of aldosterone and cortisol. Am. J. Physiol. 1965;208:1275–1280.

18) Treatment of essential hypertension with coenzyme Q10. Langsjoen P, Langsjoen P, Willis R, Folkers Mol Aspects Med. 1994; 15 Suppl():S265-72.

19) Qayyum R, Qamar HM, Khan S, Salma U, Khan T, Shah AJ. Mechanisms underlying the antihypertensive properties of Urtica dioica. J Transl Med. 2016 Sep 1;14(1):254.

20) Qayyum R, Qamar HM, Khan S, Salma U, Khan T, Shah AJ. Mechanisms underlying the antihypertensive properties of Urtica dioica. J Transl Med. 2016 Sep 1;14(1):254.

21) Vajic UJ, Grujic-Milanovic J, Miloradovic Z, Jovovic D, Ivanov M, Karanovic D, Savikin K, Bugarski B, Mihailovic-Stanojevic N. Urtica dioica L. leaf extract modulates blood pressure and oxidative stress in spontaneously hypertensive rats. Phytomedicine. 2018 Jul 15;46:39-45.

33) Amin MM, Asaad GF, Abdel Salam RM, El-Abhar HS, Arbid MS. Novel CoQ10 antidiabetic mechanisms underlie its positive effect: modulation of insulin and adiponectine receptors, Tyrosine kinase, PI3K, glucose transporters, sRAGE and visfatin in insulin resistant/diabetic rats. PLoS One. 2014 Feb 20;9(2):e89169.

34) El-ghoroury EA, Raslan HM, Badawy EA, El-Saaid GS, Agybi MH, Siam I, Salem SI. Malondialdehyde and coenzyme Q10 in platelets and serum in type 2 diabetes mellitus: correlation with glycemic control. Blood Coagul Fibrinolysis. 2009 Jun;20(4):248–

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